My Medical Blog http://mymedblog.com/ ru My Medical Blog DataLife Engine PEPCID: DOSAGE AND ADMINISTRATION http://mymedblog.com/pepcid/83-pepcid-dosage-and-administration.html http://mymedblog.com/pepcid/83-pepcid-dosage-and-administration.html
 


DOSAGE AND ADMINISTRATION

Duodenal Ulcer
Acute Therapy: The recommended adult oral dosage for active duodenal ulcer is 40 mg once a day at bedtime. Most patients heal within 4 weeks; there is rarely reason to use PEPCID at full dosage for longer than 6 to 8 weeks. A regimen of 20 mg b.i.d. is also effective.
Maintenance Therapy: The recommended oral dose is 20 mg once a day at bedtime.

Benign Gastric Ulcer Acute Therapy: The recommended adult oral dosage for active benign gastric ulcer is 40 mg once a day at bedtime.

Gastroesophageal Reflux Disease (GERD)
The recommended oral dosage for treatment of patients with symptoms of GERD is 20 mg b.i.d. for up to 6 weeks. The recommended oral dosage for the treatment of patients with esophagitis including erosions and ulcerations and accompanying symptoms due to GERD is 20 or 40 mg b.i.d. for up to 12 weeks]]> support Thu, 26 Feb 2009 21:22:08 +0300 PEPCID: INDICATIONS AND USAGE http://mymedblog.com/pepcid/82-pepcid-indications-and-usage.html http://mymedblog.com/pepcid/82-pepcid-indications-and-usage.html
 


INDICATIONS AND USAGE

PEPCID is indicated in:
  1. Short term treatment of active duodenal ulcer. Most patients heal within 4 weeks; there is rarely reason to use PEPCID at full dosage for longer than 6 to 8 weeks. Studies have not assessed the safety of famotidine in uncomplicated active duodenal ulcer for periods of more than eight weeks.
  2. Maintenance therapy for duodenal ulcer patients at reduced dosage after healing of an active ulcer.Controlled studies have not extended beyond one year.
  3. Short term treatment of active benign gastric ulcer. Most patients heal within 6 weeks. Studies have not assessed the safety or efficacy of famotidine in uncomplicated active benign gastric ulcer for periods of more than 8 weeks.
  4. Short term treatment of gastroesophageal reflux disease (GERD). PEPCID is indicated for short term treatment of patients with symptoms of GERD.PEPCID is also indicated for the short term treatment of esophagitis due to GERD including erosive or ulcerative disease diagnosed by endoscopy.
  5. Treatment of pathological hypersecretory conditions (e.g., Zollinger-Ellison Syndrome, multiple endocrine adenomas).
]]> support Thu, 26 Feb 2009 20:29:43 +0300 PEPCID: CLINICAL STUDIES http://mymedblog.com/pepcid/81-pepcid-clinical-studies.html http://mymedblog.com/pepcid/81-pepcid-clinical-studies.html Clinical Studies

 

Duodenal Ulcer
In a U.S. multicenter, double-blind study in outpatients with endoscopically confirmed duodenal ulcer, orally administered PEPCID was compared to placebo. As shown in Table 1, 70% of patients treated with PEPCID 40 mg h.s. were healed by week 4.]]> support Mon, 16 Feb 2009 20:25:59 +0300 PEPCID: CLINICAL PHARMACOLOGY http://mymedblog.com/pepcid/80-pepcid-clinical-pharmacology.html http://mymedblog.com/pepcid/80-pepcid-clinical-pharmacology.html
 


CLINICAL PHARMACOLOGY

PEPCID is a competitive inhibitor of histamine H2-receptors. The primary clinically important pharmacologic activity of PEPCID is inhibition of gastric secretion. Both the acid concentration and volume of gastric secretion are suppressed by PEPCID, while changes in pepsin secretion are proportional to volume output.

In normal volunteers and hypersecretors, PEPCID inhibited basal and nocturnal gastric secretion, as well as secretion stimulated by food and pentagastrin. After oral administration, the onset of the antisecretory effect occurred within one hour; the maximum effect was dose-dependent, occurring within one to three hours. Duration of inhibition of secretion by doses of 20 and 40 mg was 10 to 12 hours.]]> support Mon, 16 Feb 2009 20:02:52 +0300 PEPCID: DESCRIPTION http://mymedblog.com/pepcid/79-pepcid-description.html http://mymedblog.com/pepcid/79-pepcid-description.html DESCRIPTION
The active ingredient in PEPCID (Famotidine) is a histamine H2-receptor antagonist.  PEPCID (Famotidine) is Ną-(aminosulfonyl)-3-[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]thio]propanimidamide. The empirical formula of famotidine is C8H15N7O2S3 and its molecular weight is 337.43.

In 3d formula looks like :
 


Its structural formula is:
 

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